TNF-α Boost Ingredients

The TNF-α SNP is supported by ingredients that specifically help regulate TNF-α levels, support a healthy inflammatory response and help fight the increased production of free radicals caused by high levels of TNF-α and aging.

Polyphenols from Green Tea, Grape Seed and Pomegranate Extracts

  • Increased polyphenol consumption supports overall health and healthy aging.
  • Green Tea polyphenols reduces the expression of TNF-α as shown in both in vitro studies and animal studies.62,63,64,65,66,67
  • Green tea extract supplementation has been shown to reduce TNF-α levels in humans.68
  • Green tea and grape seed polyphenols have been shown to modulate inflammatory response in humans.69
  • Polyphenols in pomegranate support modulation of inflammatory cell signaling by suppressing TNF-α induction of various inflammatory proteins.70
  • Polyphenol compounds in grape seed extract, known as proanthocyanidins or OPCs, help reduce the expression of the vascular cell adhesion molecule-1 gene (VACM-1),71 which plays a critical role in healthy inflammatory responses. VACM-1 is induced by TNF-α.

Milk Thistle Extract (Silymarin)

  • Silymarin helps reduce TNF-α induced activation of NF-kB. NF-kB is a nuclear transcription factor which regulates the expression of various genes involved in the inflammatory response.72
  • Silymarin helps protect against TNF-α induced production of reactive oxygen species and lipid peroxidation.72
  • Animal studies have shown Silymarin supports the inhibition of TNF-α gene expression.73

References:

  • 62. Sueoka N, et al. Ann NY Acad Sci. 2001. 928:274-80.
  • 63. Cao H, et al. J. Inflammation. 2007. 5(4):1.
  • 64. Chen PC, et al. Inflammation. 2002. 26(5):233-41.
  • 65. Wahyudi S, et al. Acta Med Indones. 2007. 39(2):66-70.
  • 66. Akhtar N. Arthritis Res There. 2011. 13(3):R93.
  • 67. Lee AS, et al. Cell Physiol Biochem. 2009. 24(5-6):502-10.
  • 68. Bogdanski P, et al. Nutr Res. 2012;32(6):421-7.
  • 69. Kawaguchi K, et al. Curr Top Med Chem. 2011. 11(14): 1767-79
  • 70. Adams LS, et al. J Agric Food Chemistry. 2006. 54(3): 980-5
  • 71. Sen CK, et al. Molecular and Cellular Biochemistry. 2001. 216(1-2): 1-7.
  • 72. Manna SK, et al. The Journal of Immunology. 1999. 163:6800-6809.
  • 73. Zi X, et al. Biochem Biophys Res Commun. 1997. 239(1): 334-9.

This information is for educational purposes only. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

 

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