TNF-α Boost Ingredients
The TNF-α SNP is supported by ingredients that specifically help regulate TNF-α levels, support a healthy inflammatory response and help fight the increased production of free radicals caused by high levels of TNF-α and aging.
Polyphenols from Green Tea, Grape Seed and Pomegranate Extracts
- Increased polyphenol consumption supports overall health and healthy aging.
- Green Tea polyphenols reduces the expression of TNF-α as shown in both in vitro studies and animal studies.62,63,64,65,66,67
- Green tea extract supplementation has been shown to reduce TNF-α levels in humans.68
- Green tea and grape seed polyphenols have been shown to modulate inflammatory response in humans.69
- Polyphenols in pomegranate support modulation of inflammatory cell signaling by suppressing TNF-α induction of various inflammatory proteins.70
- Polyphenol compounds in grape seed extract, known as proanthocyanidins or OPCs, help reduce the expression of the vascular cell adhesion molecule-1 gene (VACM-1),71 which plays a critical role in healthy inflammatory responses. VACM-1 is induced by TNF-α.
Milk Thistle Extract (Silymarin)
- Silymarin helps reduce TNF-α induced activation of NF-kB. NF-kB is a nuclear transcription factor which regulates the expression of various genes involved in the inflammatory response.72
- Silymarin helps protect against TNF-α induced production of reactive oxygen species and lipid peroxidation.72
- Animal studies have shown Silymarin supports the inhibition of TNF-α gene expression.73
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- 68. Bogdanski P, et al. Nutr Res. 2012;32(6):421-7.
- 69. Kawaguchi K, et al. Curr Top Med Chem. 2011. 11(14): 1767-79
- 70. Adams LS, et al. J Agric Food Chemistry. 2006. 54(3): 980-5
- 71. Sen CK, et al. Molecular and Cellular Biochemistry. 2001. 216(1-2): 1-7.
- 72. Manna SK, et al. The Journal of Immunology. 1999. 163:6800-6809.
- 73. Zi X, et al. Biochem Biophys Res Commun. 1997. 239(1): 334-9.
This information is for educational purposes only. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.